| 저자 |
Bae Youl Lee M.D.1*, Hee-Sang Kim M.D.1†, Jong Ha Lee M.D.1, Dong Hwan Yun M.D.1, Seung Don Yoo M.D.1, Dong Hwan Kim M.D.,1, Jinmann Chon M.D.1, Seung Ah Lee M.D.1, Yoo Jin Han M.D.1, Hyun Seok Lee M.D.1 |
Introduction
Despite the recent advancements in prevention and treatment of stroke, stroke remains the leading cause of disability and the fifth leading cause of death in the US. Although stroke has been believed to be a multifactorial disorder with minimal classical patterns of inheritance, accumulating evidence has shown the importance of genetic factors in stroke. Especially, it has been reported that a number of inflammatory mechanisms play a fundamental part in stroke thus, various inflammatory genes showing an association with stroke have received attention as candidate genes.
FBJ murine osteosarcoma viral oncogene homolog B(FOSB) is a protein that is encoded by the FOSB gene in humans. The FOSB gene family encode leucine zipper proteins that dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. AP-1 regulates inflammation gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, vascular injury and infections.
The aim of this study is to investigate whether the polymorphisms of FOSB genes were associated with the development of ischemic stroke (IS) in Korean population.
Method
121 IS patients (mean ± SD, 65.7 ± 12.1 years) and 291 controls (mean ± SD, 63.0 ± 9.3 years) were recruited from who visited in Stroke Center of Kyung Hee University hospital.
Two SNPs of FOSB(rs2282695; Ala39Ala, rs12373539; promoter -158) was searched using SNP database of National Center for Biotechnology Information (NCBI), and SNPs were selected and evaluated by direct sequencing. Multiple logistic regression models (codominant, dominant, and recessive models) were performed for odds ratio (OR), 95% confidence interval (CI), and P value using a genetic power calculator was estimated. The significance level for all statistical tests was set at p<0.05.
Results
The genotype and allele frequencies of the rs2282695 SNP demonstrated significant difference in IS cases and controls. the frequencies of the GG, AG, and AA genotypes were 46%, 45%, and 8.9%, respectively in the control group, and 37.2%, 43%, and 19.8%, respectively in IS group. A allele frequency of rs12373539 in control group was lower than that in IS group. (p=0.0067, OR=1.60, 95% CI=1.13-2.1).
The genotype and allele frequencies of the rs2282695 demonstrated no significant difference in IS cases and controls
Conclusion
A FOSB gene polymorphism (rs12373539) was associated with the patients with IS in Korean population.
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