| 제목 |
Oral prednisolone dose in the rate of radioisotope uptake in patients with CRPS type I after TBI |
| 소속 |
School of Medicine, Konkuk University, Departments of Rehabilitation Medicine1 |
| 저자 |
Jung Joong Kang1*, Seihee Yoon1, Jungin Kim1, Seung Hun Park1, Taehoon Kim1, Jong Moon Kim1† |
Objective
We conducted this single-center, retrospective study to compare the treatment effects between a high-dose oral steroid regimen and a low-dose one based on changes in the rate of radioisotope uptake on a 3-phase bone scintigraphy (TPBS) in patients with complex regional pain syndrome type I (CRPS I).
Methods
Of the patients with CRPS I after traumatic brain injury (TBI), 34 met inclusion/exclusion criteria and were enrolled in the current study.
Depending on the dose of steroid therapy, these patients were assigned to 2 groups: the high-dose steroid group (n=14) and the low-dose one (n=20).
Then, we compared the severity scores, the Kozin’s classification scores and the rate of radioisotope uptake in a TPBS between the 2 groups.
Results
There were no significant differences in changes in mean values of severity scores and Kozin’s classification scores at 2 weeks from baseline between the 2 groups (p>0.05).
In addition, there were also no significant differences in changes in the rate of radioisotope uptake at 2 weeks from baseline between the 2 groups (p>0.05).
Furthermore, there were no treatment-emergent adverse effects such as blood pressure elevation, impaired glycemic control, body weight gain and gastrointestinal disturbances.
Conclusions
Our results suggest that the low-dose steroid therapy is also effective for the treatment of patients with CRPS I after TBI.
It can therefore be inferred that the low-dose steroid therapy would also be considered another treatment option for patients where the occurrence of side effects might be of concern following the high-dose steroid therapy.
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Fig. 1. Steroid therapy protocol.
Fig. 2. Severity scores and Kozin’s classification scores.
Fig. 3. The rate of radioisotope uptake on 3-phase bone scintigraphy scans.
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