| 제목 |
Relationship between Serum BDNF Levels and Depressive Mood in Subacute Stroke Patients |
| 소속 |
Samsung Medical Center, Department of Rehabilitation Medicine1, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan University, Department of Health Sciences and Technology2 |
| 저자 |
Byung Chan Lee1*, Won Hyuk Chang1†, Jungsoo Lee1, Ahee Lee1,2, Heegoo Kim1,2, Yun-Hee Kim1,2 |
Objective: Brain-derived neurotrophic factor (BDNF) is involved in neuronal survival, synaptic plasticity, learning and memory, and neuroplasticity in both the intact and the damaged brain. Although serum BDNF could be used as a biomarker in major depressive disorder and bipolar disorder, there was a lack of reports with serum BDNF in stroke rehabilitation. In this study, we aimed to investigate the potential of BDNF as biomarker in stroke rehabilitation by analyzing the relationship between serum BDNF and depressive mood in subacute stroke patients.
Materials and Methods: Forty-five subacute stroke patients (mean age 62.8 yrs) were recruited in this study. All participants took the standard rehabilitation program included daily 2-hours of physical therapy and 1-hour of occupational therapy, 5 days a week, for 2 weeks during subacute stroke phase. We measured the serum BDNF, proBDNF and MMP-9 at T0 (before the standard rehabilitation program), T1 (1 week after the standard rehabilitation program) and T2 (2 weeks after the standard rehabilitation program). In addition, all participants were assessed with geriatric depression scale-short form (GDS-SF) for depressive mood and K-MMSE for cognitive function at three time points. Pearson correlation analysis was performed to determine the relationship between serum BDNF and each variable.
Results: Each depressive mood and cognitive function showed significantly improvement during the standard rehabilitation program for 2 weeks (p<0.05). GDS-SF at T1 was significantly correlated with serum BDNF at T1 (p<0.05). In addition, improvement of GDS-SF from T0 to T2 tended to be correlation with serum BDNF at T0 without statistical significance. There was no significant relationship between serum BDNF and K-MMSE at any time point. However, K-MMSE at T0 was significantly correlated with serum proBDNF level at T0 (p<0.05).
Conclusion: These results might suggest serum BDNF could be used as biomarker for depressive mood in subacute stroke patients. In addition, serum proBDNF might be regarded as the precursor of cognitive function in subacute stroke patients. However, further study with larger participants should be needed to clarify these results |
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