| 제목 |
Different Functional Recovery Pattern According to Sex in the First-ever Strokes in Korea |
| 소속 |
Samsung Medical Center, Sungkyunkwan University School of Medicine, Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute1, Pusan National University School of Medicine, Pusan National University Yangsan Hospital , Department of Rehabilitation Medicine2, Chungnam National University School of Medicine, Department of Rehabilitation Medicine3, Konkuk University School of Medicine, Department of Rehabilitation Medicine4, Yonsei University College of Medicine, Department and Research Institute of Rehabilitation Medicine5, Chonnam National University Medical School, Department of Physical and Rehabilitation Medicine6, Wonkwang University, School of Medicine, Department of Preventive Medicine7, Kyungpook National University School of Medicine, Kyungpook National University Hospital, Department of Rehabilitation Medicine8, Wonkwang University School of Medicine, Department of Rehabilitation Medicine9, Jeju National University Hospital, Jeju National University School of Medicine, Department of Rehabilitation Medicine10, Hallym University, Department of Statistics11, Ewha Womans University, Department of Health Convergence12, Korea Centers for Disease Control and Prevention, Division of Chronic Disease Prevention, Center for Disease13, Korea Centers for Disease Control and Prevention, Division of Chronic Disease Control, Center for Disease Prevention14, Sungkyunkwan University, School of Mechanical Engineering15, Sungkyunkwan University, Department of Health Science and Technology, Department of Medical Device Management and Research, SAIHST16 |
| 저자 |
Min-A Shin1*, Won Hyuk Chang1, Deog Yung Kim2, Min Kyun Sohn3, Jongmin Lee4, Sam-Gyu Lee5, Yong-il Shin6, Soo-Yeon Kim6, Gyung-Jae Oh7, Yang-Soo Lee8, Min Cheol Joo9, Eun Young Han10, Jun Hee Han11, Jeonghoon Ahn12, Yong-Joo Choi13, Sung Hyun Kang13, Kang Hee Lee13, Young Taek Kim14, Minyoung Shin1, Yun-Hee Kim1,15† |
Objective: The objective of this study was to investigate differences of functional recovery pattern between men and women and identify the factors associated with functional recovery pattern according to sex in stroke patients.
Materials and Methods: This study was an interim analysis of the Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) designed as 10 years long-term follow-up study of stroke patients. In this study, we analyzed 10,636 stroke patients to investigate differences in demographics and clinical features between male and female stroke patients. Serial data up to 24 months of multi-facet functional assessments such as Korean-Modified Barthel Index (K-MBI), Fugl-Meyer Assessment (FMA), Functional ambulation classification (FAC), American Speech-Language-Hearing Association-National Outcomes Measurement System (ASHA-NOMS), Korean version of Frenchay Aphasia Screening Test (K-FAST) were analyzed to identify differences in recovery patterns and factors associated with these recovery patterns according to sex in the first-ever stroke patients after adjustments for difference with age, educational level, initial stroke severity, premorbid functional level, degree of comorbidity, and multi-facet functional levels at 7 day after stroke.
Results: Out of total 10,636 stroke patients (6,043 male and 4,593 female), female patients showed significantly older age, lower education level, lower body mass index, worse premorbid functional level, higher co-morbidity and more severe initial severity assessed by NIHSS compared with male stroke patients (p<0.05, Table 1). Even after multiple adjustments for differences, multi-facet functional outcomes were more severe in female stroke patients such as lower FMA, K-FAST, and FAC at 7 day; lower K-MBI, K-FAST, and FAC at 3, 12, and 24 months; lower ASHA-NOMS at 24 months (p<0.05, Table 2).
Conclusion: These results revealed that there are sex-specific differences in multi-facet functional recoveries in stroke patients. The results of this study could provide more specific information for establishing the stroke rehabilitation strategy according to sex.
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Table 1. Demographics and clinical features in male and female stroke patients.
Table 2. Differences in functional assessment score between male and female stroke patients after multiple adjustments using analysis of covariance.
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