| 제목 |
Occurrence and risk factors of post-stroke Complex Regional Pain Syndrome |
| 소속 |
Kangbuk Samsung Medical Center, Department of Rehabilitation Medicine1 |
| 저자 |
Jae Hyeong Choi1*, Jong Geol Do1†, Yong Taek Lee1, Kyung Jae Yoon1, Jung sang Lee1, Kun Woo Kim1, Jin Tae Hwang1 |
Objective : To report occurrence and identify clinical features and risk factors of post-stroke CRPS(Complex Regional Pain Syndrome) in patients with first-ever stroke in acute rehabilitation center
Design : Retrospective single center study
Participants : First-ever stroke patients(N=377）who discharge acute rehabilitation center from Jan 2015 to Apr 2018
Main Outcome measurement : Occurrence and risk factors of CRPS diagnosed by 3-Phase bone scan on the basis of clinical suspicion in first-ever stroke patients
Statistics : Chi-square test, Mann-Whitney U-test were used to determine significant differences in occurrence of CRPS in respect to demographic, clinical features. Multivariable logistic regression analyses were performed to identify variables associated with occurrence of post-stroke CRPS. P-value<0.05 was considered to indicate statistical significance. All statistical analyses were done with IBM SPSS Statistics 24.
Results : The study population included 377 participants(173 women and 204 men). Occurrence of post-stroke CRPS in first-ever stroke patient is 30/377 (7.95%). The mean age of the CRPS group was 69.60 and 56.7% of the women were predominant. CRPS occurred after an average of 72.10 days after stroke. The interval between the stroke onset date and the rehabilitation start date did not show a significant difference between CRPS groups. In univariable analysis, there’s significant difference between two groups(CRPS group versus Non-CRPS group) for (Mann-Whitney U test) MMSE(P=0.014), K-MBI(P<0.001), FMA-UE(P<0.001), FMA-LE(P<0.001), Grip strength(P<0.001), Albumin(P=0.042), AST(P=0.023), D-Dimer(P=0.006). But, in multivariable logistic regression analysis, associated factors was only FMA-UE([OR]0.946 [CI] 0.897-0.998).
Conclusion : Post stroke CRPS occurred in 7.95% of first-ever stroke patients, which is not uncommon. Initial FMA-UE was related to the development of CRPS. For accurate prevalence and risk factor identification, multicenter prospective surveillance is required. |
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Demographic, clinical and laboratory features of patients with CRPS or without CRPS
Association between covariates and CRPS occurrence
The interval from the point of stroke occurrence to the point of CRPS occurrence
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