| 제목 |
Correlation of Bone Mineral Density with Pulmonary Function in Advanced Duchenne Muscular Dystrophy |
| 소속 |
Gangnam Severance Hospital, Department of Rehabilitation Medicine and Rehabiliation Institute of Neuromuscular Disase1, National Health Insurance Service Ilsan Hospital, Department of Physical Medicine and Rehabilitation2, Yonsei University College of Medicine, Pulmonary Rehabiliation Center3, Bundang CHA, Department of Physical Medicine and Rehabilaition4 |
| 저자 |
Justin Byun1*, Jang Woo Lee2, Han Eol Cho1,3, Won Ah Choi1,3, Seong-Woong Kang1,3†, Mi Ri Suh4, Soojin Choi2 |
Objective: The purpose of the study is to determine whether pulmonary function, including respiratory muscle strength is related to bone mineral density (BMD) in advanced Duchenne muscular dystrophy (DMD) patients.
Materials and Methods: This single-center, cross-sectional study aimed to determine whether pulmonary function, including respiratory muscle strength, is related to BMD in patients with advanced DMD. All patients included in the study were over 20 years of age and admitted to the Gangnam Severance Hospital from March 2013 to June 2017. They were nonambulatory and supported by mechanical ventilators. The patients’ age, weight, and pulmonary function as well as the BMD of the first and the fourth lumbar vertebra were assessed. A bivariate correlation for BMD and other parameters was calculated, and hierarchical regression analysis was used to determine predictors of spine Z-score.
Results: The decrease of BMD of spine was not significantly correlated with age. However, body mass index (BMI) and the parameters of pulmonary function such as forced vital capacity (FVC), maximal insufflation capacity (MIC), unassisted and assisted peak cough flow (UPCF and APCF), maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) were correlated with BMD. Hierarchical regression analysis showed BMI, MIC, UPCF and APCF were powerful predictors of spine BMD.
Conclusion: The BMD of lumbar spine correlated with BMI and some parameters of pulmonary function in DMD patients with advanced stage. |
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